The activity of target nucleases is a hallmark of infections and other diseases that can be detected by designing specific and highly sensitive oligonucleotide probes that generate a response/signal when cleaved by the enzyme.
The detection of nuclease activity is the differential element that SOMAprobes exploits to develop its oligonucleotide probes. These probes are versatile and can be implemented on standard immunoassay platforms including lateral flow, point-of-care devices, and mid- and high-throughput platforms present in every hospital laboratory.
Biomarker discovery (Nuclease)
Oligonucleotide substrate characterization
Implementation of detection system
Applications of our technology
SOMAprobes’ technology enables a novel, differential and versatile IVD platform with broad application:
Our technology has the advantage of being easily adaptable to any immunoassay technique.
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Technologies that enable the rapid detection and localization of bacterial infections in living animals could address an unmet need for infectious disease diagnostics. We describe a molecular imaging approach for the specific, noninvasive detection of S. aureus based on the activity of the S. aureus secreted nuclease, micrococcal nuclease (MN). Several short synthetic oligonucleotides, rendered resistant to mammalian serum nucleases by various chemical modifications and flanked with a fluorophore and quencher, were activated upon degradation by purified MN and in S. aureus culture supernatants.